Article
The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo.
Molecular pharmacology - 1 May 2003
Salas Ramiro, Orr-Urtreger Avi, Broide Ron S, Beaudet Arthur, Paylor Richard, De Biasi Mariella
Abstract excerpt
Nicotine, acting at pentameric neuronal nicotinic acetylcholine receptors (nAChRs), is the primary addictive component in tobacco. At low doses, it affects attention, learning, memory, anxiety, cardiovascular responses, thermoregulation, and nociception. At high doses, nicotine produces more drastic behaviors and eventually induces tonic-clonic seizures in rodents. In mammals, several subunits of the nAChRs have...
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