Article
Nicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward-related behaviours.
Genes, brain, and behavior - 1 Jul 2013
Powers M S, Broderick H J, Drenan R M, Chester J A
Abstract excerpt
Evidence is emerging that neuronal nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine (DA) system are involved in mediating the reinforcing effects of alcohol. Midbrain DA neurons express high levels of α6 subunit-containing nAChRs that modulate DA transmission, implicating their involvement in reward-related behaviours. This study assessed the role of α6-containing nAChRs in modulating alcohol...
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