Article

Alteration of empathy-related behaviors in two strains of mice expressing mutations of the α5 cholinergic nicotinic receptor subunit

2026-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Human genetic association studies have linked a single nucleotide polymorphism (SNP) of the alpha5 subunit of nicotinic acetylcholine receptors (nAChRs) to an increased risk of nicotine dependence, alcohol use disorders (AUDs) and schizophrenia. We used transgenic mice expressing either the SNP rs16969968 (termed α5SNP or α5KI) or a knockout of the Chrna5 gene (α5KO) to investigate the role of...

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Literature Corpus work: fc19fe6e-ce93-5487-96c6-46d80fea2e72
DOI: 10.64898/2026.01.13.698088

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