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Article

Nicotine consumption is regulated by a human polymorphism in dopamine neurons.

Molecular psychiatry - 1 Aug 2014

Morel C, Fattore L, Pons S, Hay Y A, Marti F, Lambolez B, De Biasi M, Lathrop M, Fratta W, Maskos U, Faure P

Abstract excerpt

Smoking is the most important preventable cause of morbidity and mortality worldwide. Recent genome-wide association studies highlighted a human haplotype on chromosome 15 underlying the risk for tobacco dependence and lung cancer. Several polymorphisms in the CHRNA3-CHRNA5-CHRNB4 cluster coding for the nicotinic acetylcholine receptor (nAChR) α3, α5 and β4 subunits were implicated. In mouse models, we define a...

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Source

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Identifiers

PMID: 24296975
DOI: 10.1038/mp.2013.158
PMCID: PMC8596967

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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