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Article

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance.

mBio - 5 Jul 2016

LaMonte Gregory, Lim Michelle Yi-Xiu, Wree Melanie, Reimer Christin, Nachon Marie, Corey Victoria, Gedeck Peter, Plouffe David, Du Alan, Figueroa Nelissa, Yeung Bryan, Bifani Pablo, Winzeler Elizabeth A

Abstract excerpt

UNLABELLED: Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage parasites. Here, we show that pfcarl encodes a protein, with a predicted molecular weight of...

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Identifiers

PMID: 27381290
DOI: 10.1128/mBio.00696-16
PMCID: PMC4958248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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