Article
Mechanistic insights into dual-active liver and blood-stage antiplasmodials.
mBio - 14 Jan 2026
Rawat Mukul, Boonyalai Nonlawat, Smidt Cindy, Luth Madeline R, Chen Daisy, Plater Andrew, Post John, Lin De, McMillan Joel, Eadsforth Thomas, Moliner-Cubel Sonia, Billker Oliver, Rayner Julian C, Gamo Fransisco-Javier, Baragaña Beatriz, Winzeler Elizabeth A, Lee Marcus C S
Abstract excerpt
The identification of novel antimalarials with activity against both the liver and blood stages of the parasite lifecycle would have the dual benefit of prophylactic and curative potential. However, one challenge of leveraging chemical hits from phenotypic screens is subsequent target identification. Here, we use in vitro evolution of resistance to investigate nine compounds from the Tres Cantos Antimalarial Set...
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