Article
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature - 1 Dec 2019
Kim Jonathan, Tan Yong Zi, Wicht Kathryn J, Erramilli Satchal K, Dhingra Satish K, Okombo John, Vendome Jeremie, Hagenah Laura M, Giacometti Sabrina I, Warren Audrey L, Nosol Kamil, Roepe Paul D, Potter Clinton S, Carragher Bridget, Kossiakoff Anthony A, Quick Matthias, Fidock David A, Mancia Filippo
Abstract excerpt
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide1. Clinical resistance to...
Topics
- Chloroquine
- Cryoelectron Microscopy
- Drug Resistance
- Hydrogen-Ion Concentration
- Malaria, Falciparum
- Membrane Transport Proteins
- Models, Molecular
- Mutation
- Plasmodium falciparum