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Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

14 Apr 2020

Abstract excerpt

A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent transmission and block infection in animal models. But despite the identification of resistance mechanisms in P. falciparum, the mode of action of IZPs remains unknown....

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PMID: 32286267
DOI: 10.1038/s41467-020-15440-4

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