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Article

Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.

ACS infectious diseases - 11 Nov 2016

Magistrado Pamela A, Corey Victoria C, Lukens Amanda K, LaMonte Greg, Sasaki Erika, Meister Stephan, Wree Melanie, Winzeler Elizabeth, Wirth Dyann F

Abstract excerpt

MMV007564 is a novel antimalarial benzimidazolyl piperidine chemotype identified in cellular screens. To identify the genetic determinant of MMV007564 resistance, parasites were cultured in the presence of the compound to generate resistant lines. Whole genome sequencing revealed distinct mutations in the gene named Plasmodium falciparum cyclic amine resistance locus (pfcarl), encoding a conserved protein of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27933786
DOI: 10.1021/acsinfecdis.6b00025
PMCID: PMC5109296

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