Article

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe cases

2020-11-14

Abstract excerpt

Sequestration of Plasmodium falciparum -infected erythrocytes to host endothelium through the parasite-derived Pf EMP1 adhesion proteins is central to the development of malaria pathogenesis. Pf EMP1 proteins have diversified and expanded to encompass many sequence variants conferring each parasite a similar array of human endothelial receptor binding phenotypes. Here, we analyzed RNA-seq profiles of parasites...

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Literature Corpus work: 3c7f3adf-aa3b-5b64-bb78-1e6f50f2fae2
DOI: 10.1101/2020.11.13.381137

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