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Article

Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria.

Malaria journal - 16 Jul 2012

Mugasa Joseph, Qi Weihong, Rusch Sebastian, Rottmann Matthias, Beck Hans-Peter

Abstract excerpt

BACKGROUND: Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary venules of vital organs such as the brain, lung or placenta. var genes are highly diverse and can be classified in three...

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Identifiers

PMID: 22799500
DOI: 10.1186/1475-2875-11-230
PMCID: PMC3488018

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