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<i>Plasmodium falciparum</i> erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

22 May 2012

Abstract excerpt

The clinical outcome of Plasmodium falciparum infections ranges from asymptomatic parasitemia to severe malaria syndromes associated with high mortality. The virulence of P. falciparum infections is associated with the type of P. falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the surface of infected erythrocytes to anchor these to the vascular lining. Although var2csa, the var gene encoding the...

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PMID: 22619319
DOI: 10.1073/pnas.1120455109

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