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Article

Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults.

mBio - 30 Apr 2019

Duffy Fergal, Bernabeu Maria, Babar Prasad H, Kessler Anne, Wang Christian W, Vaz Marina, Chery Laura, Mandala Wilson L, Rogerson Stephen J, Taylor Terrie E, Seydel Karl B, Lavstsen Thomas, Gomes Edwin, Kim Kami, Lusingu John, Rathod Pradipsinh K, Aitchison John D, Smith Joseph D

Abstract excerpt

The clinical presentation of severe Plasmodium falciparum malaria differs between children and adults, but the mechanistic basis for this remains unclear. Contributing factors to disease severity include total parasite biomass and the diverse cytoadhesive properties mediated by the polymorphic var gene parasite ligand family displayed on infected erythrocytes. To explore these factors, we performed a multicohort...

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PMID: 31040236
DOI: 10.1128/mBio.00217-19
PMCID: PMC6495371

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