Article
Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.
Cell host & microbe - 14 Jan 2015
Lau Clinton K Y, Turner Louise, Jespersen Jakob S, Lowe Edward D, Petersen Bent, Wang Christian W, Petersen Jens E V, Lusingu John, Theander Thor G, Lavstsen Thomas, Higgins Matthew K
Abstract excerpt
The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and must retain the ability to bind to host receptors while also diversifying to aid immune evasion. The interaction between CIDRα1 domains of PfEMP1 and endothelial protein C receptor (EPCR) is associated with severe childhood malaria. We combine crystal structures of CIDRα1:EPCR complexes with analysis of 885 CIDRα1 sequences,...
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