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PfEMP1-DBL1α amino acid motifs in severe disease states of <i>Plasmodium falciparum</i> malaria

25 Sept 2007

Abstract excerpt

An infection with Plasmodium falciparum may lead to severe malaria as a result of excessive binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by P. falciparum erythrocyte membrane protein-1 (PfEMP1), which is encoded for by highly polymorphic members of the var-gene family. Here, we profile var gene transcription in fresh P. falciparum trophozoites from Ugandan children with...

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PMID: 17895392
DOI: 10.1073/pnas.0610485104

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