Article
Information recovery from low coverage whole-genome bisulfite sequencing.
Nature communications - 27 Jun 2016
Libertini Emanuele, Heath Simon C, Hamoudi Rifat A, Gut Marta, Ziller Michael J, Czyz Agata, Ruotti Victor, Stunnenberg Hendrik G, Frontini Mattia, Ouwehand Willem H, Meissner Alexander, Gut Ivo G, Beck Stephan
Abstract excerpt
The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution features such as differentially methylated positions (DMPs) cannot be called with current methods as...
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