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Article

Targeted alignment and end repair elimination increase alignment and methylation measure accuracy for reduced representation bisulfite sequencing data.

BMC genomics - 27 Feb 2016

Baheti Saurabh, Kanwar Rahul, Goelzenleuchter Meike, Kocher Jean-Pierre A, Beutler Andreas S, Sun Zhifu

Abstract excerpt

BACKGROUND: DNA methylation is an important epigenetic modification involved in many biological processes. Reduced representation bisulfite sequencing (RRBS) is a cost-effective method for studying DNA methylation at single base resolution. Although several tools are available for RRBS data processing and analysis, it is not clear which strategy performs the best and there has not been much attention to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26922377
DOI: 10.1186/s12864-016-2494-8
PMCID: PMC4769831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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