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Analyzing the cancer methylome through targeted bisulfite sequencing.

Cancer letters - 1 Nov 2013

Lee Eun-Joon, Luo Junfeng, Wilson James M, Shi Huidong

Abstract excerpt

Bisulfite conversion of genomic DNA combined with next-generation sequencing (NGS) has become a very effective approach for mapping the whole-genome and sub-genome wide DNA methylation landscapes. However, whole methylome shotgun bisulfite sequencing is still expensive and not suitable for analyzing large numbers of human cancer specimens. Recent advances in the development of targeted bisulfite sequencing...

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Computational Biology
DNA Methylation
Gene Expression Regulation, Neoplastic
Genome, Human
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Predictive Value of Tests

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PMID: 23200671
DOI: 10.1016/j.canlet.2012.10.040
PMCID: PMC3616138

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