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Article

Mutation patterns and evolutionary action score of TP53 enable identification of a patient population with poor prognosis in advanced non-small cell lung cancer.

Cancer medicine - 1 Mar 2023

Jiang Wensheng, Cheng Huanqing, Yu Lili, Zhang Jie, Wang Yihui, Liang Yun, Lou Feng, Wang Huina, Cao Shanbo

Abstract excerpt

BACKGROUND: TP53 mutations are frequent in non-small cell lung cancer (NSCLC). Different categories of TP53 mutations may be associated with survival in advanced NSCLC, but their effect on prognosis is diverse. To date, a comprehensive comparison of the relationship between different classes of TP53 alterations and survival in advanced NSCLC has rarely been performed. Moreover, the prognostic significance of a...

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Identifiers

PMID: 36440695
DOI: 10.1002/cam4.5447
PMCID: PMC10067094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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