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Article

High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma.

Oral diseases - 1 May 2024

Caponio Vito Carlo Alberto, Zhurakivska Khrystyna, Mascitti Marco, Togni Lucrezia, Spirito Francesca, Cirillo Nicola, Lo Muzio Lorenzo, Troiano Giuseppe

Abstract excerpt

OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) poses a diagnostic and therapeutic challenge worldwide and is associated with a poor survival rate. Due to the variability in the efficacy of treatments for HNSCC, new predictive biomarkers of therapy outcomes are needed. Recently, we developed an algorithm that employs the mutational profile of TP53 as an independent prognostic factor in HNSCC. In this...

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PMID: 37501500
DOI: 10.1111/odi.14698

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