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Article

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.

Cancer research - 1 Apr 2015

Neskey David M, Osman Abdullah A, Ow Thomas J, Katsonis Panagiotis, McDonald Thomas, Hicks Stephanie C, Hsu Teng-Kuei, Pickering Curtis R, Ward Alexandra, Patel Ameeta, Yordy John S, Skinner Heath D, Giri Uma, Sano Daisuke, Story Michael D, Beadle Beth M, El-Naggar Adel K, Kies Merrill S, William William N, Caulin Carlos, Frederick Mitchell, Kimmel Marek, Myers Jeffrey N, Lichtarge Olivier

Abstract excerpt

TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remains elusive. In the current study, we evaluated a novel computational approach termed evolutionary action...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25634208
DOI: 10.1158/0008-5472.CAN-14-2735
PMCID: PMC4383697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25634208-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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