Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease.

doi:10.3233/JAD-150749

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Article

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 18 Jun 2016

Chouraki Vincent, Reitz Christiane, Maury Fleur, Bis Joshua C, Bellenguez Celine, Yu Lei, Jakobsdottir Johanna, Mukherjee Shubhabrata, Adams Hieab H, Choi Seung Hoan, Larson Eric B, Fitzpatrick Annette, Uitterlinden Andre G, de Jager Philip L, Hofman Albert, Gudnason Vilmundur, Vardarajan Badri, Ibrahim-Verbaas Carla, van der Lee Sven J, Lopez Oscar, Dartigues Jean-François, Berr Claudine, Amouyel Philippe, Bennett David A, van Duijn Cornelia, DeStefano Anita L, Launer Lenore J, Ikram M Arfan, Crane Paul K, Lambert Jean-Charles, Mayeux Richard, Seshadri Sudha

Abstract excerpt

Effective prevention of Alzheimer's disease (AD) requires the development of risk prediction tools permitting preclinical intervention. We constructed a genetic risk score (GRS) comprising common genetic variants associated with AD, evaluated its association with incident AD and assessed its capacity to improve risk prediction over traditional models based on age, sex, education, and APOEɛ4. In eight prospective...

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PMID: 27340842
DOI: 10.3233/JAD-150749
PMCID: PMC5036102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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