Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Disentangling the genetic constellation underlying Alzheimer’s disease (AD) is important. Doing so allows us to identify biological pathways underlying AD, point towards novel drug targets and use the variants for individualised risk predictions in disease modifying or prevention trials. In the present work we report on the largest genome-wide association study (GWAS) for AD r...

Topics

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• Age of Onset
• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Apolipoproteins E
• Datasets as Topic
• Follow-Up Studies
• Multifactorial Inheritance
• Risk Assessment

Identifiers and source

Literature Corpus work

491a6231-64b5-54ae-96a2-d83b4d7f2e3c

DOI

10.1101/19012021