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Article

Association of catechol-O-methyltransferase Val(108/158) Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population.

Psychiatry research - 30 Aug 2016

Mao Qiao, Tan Yun-Long, Luo Xing-Guang, Tian Li, Wang Zhi-Ren, Tan Shu-Ping, Chen Song, Yang Gui-Gang, An Hui-Mei, Yang Fu-De, Zhang Xiang-Yang

Abstract excerpt

Catechol-O-methyltransferase (COMT), an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, is associated with the sensory gating phenomenon, protecting the cerebral cortex from information overload. The COMT Val(108/158)Met polymorphism is essential for prefrontal cortex processing capacity and efficiency. The current study was designed to investigate the role of COMT...

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Identifiers

PMID: 27315458
DOI: 10.1016/j.psychres.2016.04.029

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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