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Article

The effects of catechol-O-methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta-analysis.

PsyCh journal - 1 Dec 2022

Misir Emre, Ozbek Mutlu Muhammed, Halac Eren, Turan Serkan, Alkas Gokce Elif, Ciray Remzi Ogulcan, Ermis Cagatay

Abstract excerpt

The catechol-O-methyltransferase (COMT) gene is thought to have an important role in the etiopathogenesis of schizophrenia, but there are conflicting results regarding its role in clinical presentation. We aimed to elucidate the relationship between the single nucleotide polymorphisms (SNPs) in the COMT gene and the severity of positive and negative symptoms. In order to investigate the relationship, the PubMed,...

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Identifiers

PMID: 35642295
DOI: 10.1002/pchj.562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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