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Article

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.

Neuromolecular medicine - 1 Jun 2016

González-Castro Thelma Beatriz, Hernández-Díaz Yazmin, Juárez-Rojop Isela Esther, López-Narváez María Lilia, Tovilla-Zárate Carlos Alfonso, Fresan Ana

Abstract excerpt

An association between a catechol-O-methyltransferase (COMT) Val156Met (rs4680) polymorphism and schizophrenia has been reported in the literature, although no conclusive outcomes have been attained. The aim of this study was to evaluate the association of the COMT Val108/158Met polymorphism with schizophrenia in a systematic review and meta-analysis. We performed a keyword search on PubMed and EBSCO databases....

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Identifiers

PMID: 27020768
DOI: 10.1007/s12017-016-8392-z

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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