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Article

COMT Val108/158Met genotype modulates human sensory gating.

NeuroImage - 15 Mar 2011

Majic Tomislav, Rentzsch Johannes, Gudlowski Yehonala, Ehrlich Stefan, Juckel Georg, Sander Thomas, Lang Undine E, Winterer Georg, Gallinat Jürgen

Abstract excerpt

BACKGROUND: The catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism of the dopamine system is essential for prefrontal cortex processing capacity and efficiency. In addition, dopaminergic neurotransmission is also associated with the sensory gating phenomenon protecting the cerebral cortex from information overload. It is however unclear if COMT genotype as a predictor of prefrontal efficiency...

Topics

Adult
Brain
Catechol O-Methyltransferase
Electroencephalography
Evoked Potentials, Auditory
Female
Genotype
Humans
Male
Polymerase Chain Reaction
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensory Gating

Source

Identifiers

PMID: 21184832
DOI: 10.1016/j.neuroimage.2010.12.031

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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COMT Val108/158Met genotype modulates human sensory gating.PMID 21184832Read ↗

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