Article
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia.
Biological psychiatry - 1 Oct 2007
Lu Brett Y, Martin Kimberly E, Edgar J Christopher, Smith Ashley K, Lewis Stephen F, Escamilla Michael A, Miller Gregory A, Cañive Jose M
Abstract excerpt
BACKGROUND: Studies have implicated prefrontal dopamine in cortical information filtering. Deficit in stimulus filtering, an endophenotype of schizophrenia, can be demonstrated using the auditory P50 paired-click gating paradigm. The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal...
Topics
- Adult
- Amino Acid Substitution
- Antipsychotic Agents
- Catechol O-Methyltransferase
- Evoked Potentials, Auditory
- Female
- Humans
- Male
- Methionine
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Regression Analysis