Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.

doi:10.1016/j.stem.2020.06.018

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Article

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.

Cell stem cell - 6 Aug 2020

Tovy Ayala, Reyes Jaime M, Gundry Michael C, Brunetti Lorenzo, Lee-Six Henry, Petljak Mia, Park Hyun Jung, Guzman Anna G, Rosas Carina, Jeffries Aaron R, Baple Emma, Mill Jonathan, Crosby Andrew H, Sency Valerie, Xin Baozhong, Machado Heather E, Castillo Danielle, Weitzel Jeffrey N, Li Wei, Stratton Michael R, Campbell Peter J, Wang Heng, Sanders Mathijs A, Goodell Margaret A

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) is the most commonly mutated gene in clonal hematopoiesis (CH). Somatic DNMT3A mutations arise in hematopoietic stem cells (HSCs) many years before malignancies develop, but difficulties in comparing their impact before malignancy with wild-type cells have limited the understanding of their contributions to transformation. To circumvent this limitation, we derived normal and...

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Identifiers

PMID: 32673568
DOI: 10.1016/j.stem.2020.06.018
PMCID: PMC7494054

Genes

DNMT3A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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