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Article

TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia.

Journal of the neurological sciences - 15 Jul 2016

Halliday Glenda M, Kiernan Matthew C, Kril Jillian J, Mito Remika, Masuda-Suzukake Masami, Hasegawa Masato, McCann Heather, Bartley Lauren, Dobson-Stone Carol, Kwok John B J, Hornberger Michael, Hodges John R, Tan Rachel H

Abstract excerpt

The hypoglossal nucleus was recently identified as a key brain region in which the presence of TDP-43 pathology could accurately discriminate TDP-43 proteinopathy cases with clinical amyotrophic lateral sclerosis (ALS). The objective of the present study was to assess the hypoglossal nucleus in behavioral variant frontotemporal dementia (bvFTD), and determine whether TDP-43 in this region is associated with...

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PMID: 27288806
DOI: 10.1016/j.jns.2016.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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