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Article

Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions.

Neurology - 16 Feb 2016

Kim Garam, Ahmadian Saman S, Peterson Melanie, Parton Zach, Memon Rohail, Weintraub Sandra, Rademaker Alfred, Bigio Eileen, Mesulam M-Marsel, Geula Changiz

Abstract excerpt

OBJECTIVE: To investigate quantitative regional distribution and hemispheric asymmetry of TDP-43 (TAR DNA-binding protein 43) inclusions, neurons, and activated microglia in primary progressive aphasia (PPA) with progranulin (GRN) mutations, and to determine concordance between distribution of pathology, clinical phenotype, and known atrophy patterns. METHODS: Antibodies to phospho-TDP-43, NeuN (neuronal nuclei),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26791154
DOI: 10.1212/WNL.0000000000002375
PMCID: PMC4762414

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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