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Article

"Switchboard" malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis.

NeuroImage. Clinical - 1 Jan 2020

Chipika Rangariroyashe H, Finegan Eoin, Li Hi Shing Stacey, McKenna Mary Clare, Christidi Foteini, Chang Kai Ming, Doherty Mark A, Hengeveld Jennifer C, Vajda Alice, Pender Niall, Hutchinson Siobhan, Donaghy Colette, McLaughlin Russell L, Hardiman Orla, Bede Peter

Abstract excerpt

The thalamus is a key cerebral hub relaying a multitude of corticoefferent and corticoafferent connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural functions. While the thalamus consists of dozens of anatomically well-defined nuclei with distinctive physiological roles, existing imaging studies in motor neuron diseases typically evaluate the thalamus as a single structure. Based...

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Identifiers

PMID: 32554322
DOI: 10.1016/j.nicl.2020.102300
PMCID: PMC7303672

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