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Article

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.

Acta neuropathologica communications - 23 Jun 2016

Takeuchi Ryoko, Tada Mari, Shiga Atsushi, Toyoshima Yasuko, Konno Takuya, Sato Tomoe, Nozaki Hiroaki, Kato Taisuke, Horie Masao, Shimizu Hiroshi, Takebayashi Hirohide, Onodera Osamu, Nishizawa Masatoyo, Kakita Akiyoshi, Takahashi Hitoshi

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are types of major TDP-43 (43-kDa TAR DNA-binding protein) proteinopathy. Cortical TDP-43 pathology has been analyzed in detail in cases of FTLD-TDP, but is still unclear in cases of ALS. We attempted to clarify the cortical and subcortical TDP-43 pathology in Japanese cases of sporadic ALS (n = 96) using an antibody specific to...

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PMID: 27338935
DOI: 10.1186/s40478-016-0335-2
PMCID: PMC4918136

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