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Article

Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Feb 2010

Armstrong Richard A, Ellis William, Hamilton Ronald L, Mackenzie Ian R A, Hedreen John, Gearing Marla, Montine Thomas, Vonsattel Jean-Paul, Head Elizabeth, Lieberman Andrew P, Cairns Nigel J

Abstract excerpt

Studies suggest that frontotemporal lobar degeneration with transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy (FTLD-TDP) is heterogeneous with division into four or five subtypes. To determine the degree of heterogeneity and the validity of the subtypes, we studied neuropathological variation within the frontal and temporal lobes of 94 cases of FTLD-TDP using quantitative estimates of...

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Identifiers

PMID: 20012109
DOI: 10.1007/s00702-009-0350-6
PMCID: PMC2830004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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