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Article

Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.

Journal of neuropathology and experimental neurology - 1 Sept 2017

Takeda Takahiro, Seilhean Danielle, Le Ber Isabelle, Millecamps Stéphanie, Sazdovitch Véronique, Kitagawa Kazuo, Uchihara Toshiki, Duyckaerts Charles

Abstract excerpt

TDP-43-positive inclusions are present in the amygdala in frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND) including amyotrophic lateral sclerosis. Behavioral abnormalities, one of the chief symptoms of FTLD, could be, at least partly, related to amygdala pathology. We examined TDP-43 inclusions in the amygdala of patients with sporadic FTLD/MND (sFTLD/MND), FTLD/MND with mutation of the...

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PMID: 28859337
DOI: 10.1093/jnen/nlx063

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GRN

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