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Article

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.

Acta neuropathologica communications - 6 Sept 2017

Yousef Ahmed, Robinson John L, Irwin David J, Byrne Matthew D, Kwong Linda K, Lee Edward B, Xu Yan, Xie Sharon X, Rennert Lior, Suh EunRan, Van Deerlin Vivianna M, Grossman Murray, Lee Virginia M-Y, Trojanowski John Q

Abstract excerpt

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if cortical neurons detected by NeuN decreased with increasing TDP-43 inclusion pathology in the postmortem brains of 63 patients with sporadic and familial FTLD-TDP. Semi-automated quantitative...

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Identifiers

PMID: 28877758
DOI: 10.1186/s40478-017-0471-3
PMCID: PMC5586052

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