[¹⁸F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia

Abstract excerpt

Introduction Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology. It provides a useful model in which to test the specificity of in vivo binding of the putative tau ligand [ 18 F]AV-1451, which is elevated in frontotemporal lobar degeneration tauopathies. Methods and results Seven patients (five...

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