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Article

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore.

PLoS biology - 1 Jun 2016

Wray Robin, Iscla Irene, Gao Ya, Li Hua, Wang Junmei, Blount Paul

Abstract excerpt

The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins; however, the routes by which it enters the bacterial cell are largely unknown. The mechanosensitive channel of large conductance, MscL, is found in the vast majority of bacterial species, where it serves as an...

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Identifiers

PMID: 27280286
DOI: 10.1371/journal.pbio.1002473
PMCID: PMC4900634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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