Article
Characterization of three novel mechanosensitive channel activities in Escherichia coli.
Channels (Austin, Tex.) - 1 Jan 2000
Edwards Michelle D, Black Susan, Rasmussen Tim, Rasmussen Akiko, Stokes Neil R, Stephen Terri-Leigh, Miller Samantha, Booth Ian R
Abstract excerpt
Mechanosensitive channels sense elevated membrane tension that arises from rapid water influx occurring when cells move from high to low osmolarity environments (hypoosmotic shock). These non-specific channels in the cytoplasmic membrane release osmotically-active solutes and ions. The two major mechanosensitive channels in Escherichia coli are MscL and MscS. Deletion of both proteins severely compromises...
Topics
- Cell Membrane
- Electrophysiological Phenomena
- Escherichia coli
- Escherichia coli Proteins
- Ion Channels
- Mutation
- Osmotic Pressure
- Patch-Clamp Techniques
- Potassium Channels