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Article

Novel Tumor-specific Mutations in Receptor Tyrosine Kinase Subdomain IX Significantly Reduce Extracellular Signal-regulated Kinase Activity.

Anticancer research - 1 Jun 2016

Serizawa Masakuni, Kusuhara Masatoshi, Ohnami Sumiko, Nagashima Takeshi, Shimoda Yuji, Ohshima Keiichi, Mochizuki Tohru, Urakami Kenichi, Yamaguchi Ken

Abstract excerpt

BACKGROUND/AIM: The identification of additional therapeutic targets by clinical molecular profiling is necessary to expand the range of molecular-targeted cancer therapeutics. This study aimed to identify novel functional tumor-specific single nucleotide variants (SNVs) in the kinase domain of receptor tyrosine kinases (RTKs), from whole-exome sequencing (WES) data. MATERIALS AND METHODS: SNVs were selected from...

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Identifiers

PMID: 27272783

Genes

FLT3
NTRK1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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