Article

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer

2025-03-15

Abstract excerpt

<h4>Introduction</h4> Clinical workflows to analyze variants of unknown significance (VUSs) found in clinical next generation sequencing (NGS) are labor intensive, requiring manual analysis of published data for each variant. There is a strong need for tools and resources that provide a consistent way to analyze variants. With the explosion of clinical NGS data and the concurrent availability of protein structure...

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Literature Corpus work: 0443ea7f-f411-5014-aaa6-f94ea8369bf4
DOI: 10.1101/2025.03.13.643138

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