Predisposing deleterious variants in the cancer-associated human kinases in the global populations.

Abstract excerpt

Human kinases play essential and diverse roles in the cellular activities of maintaining homeostasis and growth. Genetic mutations in the genes encoding the kinases (or phosphotransferases) have been linked with various types of cancers. In this study, we cataloged mutations in 500 kinases genes in >65,000 individuals of global populations from the Human Genetic Diversity Project (HGDP) and ExAC databases, and...

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• Gene Expression Profiling
• FGFR3 gene
• NTRK1 gene
• Germ-Line Mutation
• Mutation