Article
Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.
Molecular genetics & genomic medicine - 1 Oct 2020
Zhang Biao, Chen Yongsheng, Dai Pingping, Yu Haoda, Ma Jianhui, Chen Chen, Zhang Yan, Guan Yanfang, Chen Rongrong, Liu Tao, Wang Jiayin, Yang Ling, Yi Xin, Xia Xuefeng, Ma Haitao
Abstract excerpt
BACKGROUND: β3-αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches on mutations within β3-αC loop in EGFR, but relatively less in ERBB2, BRAF, and MAP2K1. In addition, previous studies mainly focus on β3-αC deletion in EGFR, which is the most common type affecting kinase activity and driving lung cancer. Other...
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