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Article

Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer.

Mutation research - 1 Oct 2015

Anoosha P, Huang Liang-Tsung, Sakthivel R, Karunagaran D, Gromiha M Michael

Abstract excerpt

Cancer is one of the most life-threatening diseases and mutations in several genes are the vital cause in tumorigenesis. Protein kinases play essential roles in cancer progression and specifically, epidermal growth factor receptor (EGFR) is an important target for cancer therapy. In this work, we have developed a method to classify single amino acid polymorphisms (SAPs) in EGFR into disease-causing (driver) and...

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Source

Identifiers

PMID: 26264175
DOI: 10.1016/j.mrfmmm.2015.07.005

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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