Article
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2005
Rand Vikki, Huang Jiaqi, Stockwell Tim, Ferriera Steve, Buzko Oleksandr, Levy Samuel, Busam Dana, Li Kelvin, Edwards Jennifer B, Eberhart Charles, Murphy Kathleen M, Tsiamouri Alexia, Beeson Karen, Simpson Andrew J G, Venter J Craig, Riggins Gregory J, Strausberg Robert L
Abstract excerpt
It is now clear that tyrosine kinases represent attractive targets for therapeutic intervention in cancer. Recent advances in DNA sequencing technology now provide the opportunity to survey mutational changes in cancer in a high-throughput and comprehensive manner. Here we report on the sequence analysis of members of the receptor tyrosine kinase (RTK) gene family in the genomes of glioblastoma brain tumors....
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