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Article

Landscape of drug-resistance mutations in kinase regulatory hotspots

6 May 2020

Abstract excerpt

More than 48 kinase inhibitors (KIs) have been approved by Food and Drug Administration. However, drug-resistance (DR) eventually occurs, and secondary mutations have been found in the previously targeted primary-mutated cancer cells. Cancer and drug research communities recognize the importance of the kinase domain (KD) mutations for kinasopathies. So far, a systematic investigation of kinase mutations on DR...

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PMID: 32510566
DOI: 10.1093/bib/bbaa108

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