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Article

White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms.

Psychiatry research. Neuroimaging - 30 Jul 2016

Tatham Erica L, Ramasubbu Rajamannar, Gaxiola-Valdez Ismael, Cortese Filomeno, Clark Darren, Goodyear Bradley, Foster Jane, Hall Geoffrey B

Abstract excerpt

This study examined the impact of childhood neglect, serotonin transporter (5-HTTLPR) and brain derived neurotrophic factor (BDNF) polymorphisms on white matter (WM) integrity in major depressive disorder (MDD) using diffusion tensor imaging (DTI). Fifty-five medication-free MDD patients and 18 controls underwent diffusion tensor imaging scanning, genotyping and completed the Childhood Trauma Questionnaire. Tract...

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Source

Identifiers

PMID: 27261564
DOI: 10.1016/j.pscychresns.2016.04.014

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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