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Article

The cumulative effect of genetic polymorphisms on depression and brain structural integrity.

Human brain mapping - 1 Jun 2016

Kostic Milutin, Canu Elisa, Agosta Federica, Munjiza Ana, Novakovic Ivana, Dobricic Valerija, Maria Ferraro Pilar, Miler Jerkovic Vera, Pekmezovic Tatjana, Lecic Tosevski Dusica, Filippi Massimo

Abstract excerpt

In major depressive disorder (MDD), the need to study multiple-gene effect on brain structure is emerging. Our aim was to assess the effect of accumulation of specific SERT, BDNF and COMT gene functional polymorphisms on brain structure in MDD patients. Seventy-seven MDD patients and 66 controls underwent a clinical assessment, genetic testing and MRI scan. Compared with controls, patients were more BDNF-Val...

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Identifiers

PMID: 26956059
DOI: 10.1002/hbm.23165
PMCID: PMC6867528

Genes

BDNF
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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