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Childhood stress, serotonin transporter gene and brain structures in major depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2010

Frodl Thomas, Reinhold Elena, Koutsouleris Nikolaos, Donohoe Gary, Bondy Brigitta, Reiser Maximilian, Möller Hans-Jürgen, Meisenzahl Eva M

Abstract excerpt

The underlying neurobiology of major depression (MD) is likely to represent an interaction between genetic susceptibility and environmental factors such as stress. We investigated, in a multimodal high-resolution magnetic resonance imaging (MRI) genetic study, whether reduced hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood...

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Identifiers

PMID: 20147891
DOI: 10.1038/npp.2010.8
PMCID: PMC3055341

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