Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.

doi:10.1038/npp.2015.170

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Article

Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2016

Tozzi Leonardo, Carballedo Angela, Wetterling Friedrich, McCarthy Hazel, O'Keane Veronica, Gill Michael, Morris Derrek, Fahey Ciara, Meaney James, Frodl Thomas

Abstract excerpt

The gene expressing the FK506 binding protein 51 (FKBP5) is involved in the regulation of glucocorticoid receptor sensitivity. The rs1360780 SNP in this gene (T allele vs C homozygous) has been found to be associated with major depressive disorder (MDD). The aim of our study was to investigate whether this polymorphism might be associated with altered brain structure and function in a cohort of 40 patients with...

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PMID: 26076833
DOI: 10.1038/npp.2015.170
PMCID: PMC5130124

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FKBP5

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Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.PMID 26076833Read ↗

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